CALL FOR PAPERS Cell Signaling: Proteins, Pathways and Mechanisms Exendin-4 induces myocardial protection through MKK3 and Akt-1 in infarcted hearts
نویسندگان
چکیده
Jianfeng Du, Ling Zhang, Zhengke Wang, Naohiro Yano, Yu Tina Zhao, Lei Wei, Patrycja Dubielecka-Szczerba, Paul Y. Liu, Shougang Zhuang, Gangjian Qin, and Ting C. Zhao Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, Rhode Island; Department of Dermatology, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, Rhode Island; Department of Emergency Medicine, Alpert Medical School, Brown University, Providence, Rhode Island; Women and Infants Hospital, Alpert Medical School, Brown University, Providence, Rhode Island; Department of Plastic Surgery, Alpert Medical School, Brown University, Providence, Rhode Island; Department of Medicine, Alpert Medical School, Brown University, Providence, Rhode Island; Department of Orthopedics, Rhode Island Hospital, Alpert Medical School, Brown University, Providence, Rhode Island; Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois
منابع مشابه
Exendin-4 induces myocardial protection through MKK3 and Akt-1 in infarcted hearts.
We have demonstrated that glucagon like peptide-1 (GLP-1) protects the heart against ischemic injury. However, the physiological mechanism by which GLP-1 receptor (GLP-1R) initiates cardioprotection remains to be determined. The objective of this study is to elucidate the functional roles of MAPK kinase 3 (MKK3) and Akt-1 in mediating exendin-4-elicited protection in the infarcted hearts. Adult...
متن کاملHDAC Inhibition Elicits Myocardial Protective Effect through Modulation of MKK3/Akt-1
We and others have demonstrated that HDAC inhibition protects the heart against myocardial injury. It is known that Akt-1 and MAP kinase play an essential role in modulation of myocardial protection and cardiac preconditioning. Our recent observations have shown that Akt-1 was activated in post-myocardial infarction following HDAC inhibition. However, it remains unknown whether MKK3 and Akt-1 a...
متن کاملQuercetin Synergistically Enhances the Anticancer Efficacy of Docetaxel through Induction of Apoptosis and Modulation of PI3K/AKT, MAPK/ERK, and JAK/STAT3 Signaling Pathways in MDA-MB-231 Breast Cancer Cell Line
Docetaxel is widely used in the treatment of metastatic breast cancer. However, its effectiveness is limited due to chemoresistance and its undesirable side effects. The combination of chemotherapeutic agents and natural compounds is an effective strategy to overcome drug resistance and the ensuing inevitable toxicities. Quercetin is a natural flavonoid with strong antioxidant and anticancer ac...
متن کاملAnti-cancer properties of Escherichia coli Nissle 1917 against HT-29 colon cancer cells through regulation of Bax/Bcl-xL and AKT/PTEN signaling pathways
Objective(s): Chemotherapies used to treat colon cancer might often fail due to the emergence of chemoresistance and side effects. Escherichia coli Nissle 1917 (EcN) is a beneficial probiotic, whose molecular mechanisms in the prevention of colon cancer are yet to be fully understood. The present study assessed the anti-cancer effects of EcN treatments in human colorec...
متن کاملRole of Src signal transduction pathways in scatter factor-mediated cellular protection.
Scatter factor (SF) (hepatocyte growth factor) is a pleiotrophic cytokine that accumulates in tumors, where it may induce invasion, angiogenesis, and chemoresistance. We have studied the mechanisms by which SF and its receptor (c-Met) protect cells against the DNA-damaging agent adriamycin (ADR) as a model for chemoresistance of SF/c-Met-overexpressing tumors. Previous studies identified a phos...
متن کامل